TabKeys Safari Extension 2.0 - Customer keyboard shortcuts for Safari tab actions. (Free)

For each action, you can assign up to three characters as shortcuts, alone or in combination with Command, Option, and/or Shift. For example, you could assign lowercase “w”, uppercase “W”, and ç (Option+C) to Close Tab.

New in TabKeys 2.0: You can now define any number of web addresses, including bookmarklets, and assign a hotkey to each. If a hotkey is assigned to a web address, TabKeys will open the address in a new tab; if it's for a bookmarklet, TabKeys will run the bookmarklet in the current tab.

• Added support for opening any number of arbitrary web addresses (and bookmarklets) via hotkeys.
• Added an option to open new tabs next to the current tab.
• Hotkeys using the Command key are now supported.
• Hotkeys are now usable while a page is loading (in most cases).
• Moved TabKeys settings to their own HTML page.
• Added a toolbar button to access the settings page. You can also type Command-Shift-, (that's a comma) to go there. (And of course that hotkey is configurable too.)
• Removed the Go Back and Go Forward actions because they were not working well. If possible, these actions will be restored in a later version.

• Mac OS X 10.5.8 or later.
• Safari 5.